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Davari, S., Shirkhanloo, H., Motakef Kazemi, N. (2017). Application of Nanoanalysis: Amine-Functionalized Mesoporous Silica nanoparticles for Mercury Speciation in Human Samples. Journal of Nanoanalysis, 4(3), 181-188. doi: 10.22034/jna.2017.539360
Sara Davari; Hamid Shirkhanloo; Negar Motakef Kazemi. "Application of Nanoanalysis: Amine-Functionalized Mesoporous Silica nanoparticles for Mercury Speciation in Human Samples". Journal of Nanoanalysis, 4, 3, 2017, 181-188. doi: 10.22034/jna.2017.539360
Davari, S., Shirkhanloo, H., Motakef Kazemi, N. (2017). 'Application of Nanoanalysis: Amine-Functionalized Mesoporous Silica nanoparticles for Mercury Speciation in Human Samples', Journal of Nanoanalysis, 4(3), pp. 181-188. doi: 10.22034/jna.2017.539360
Davari, S., Shirkhanloo, H., Motakef Kazemi, N. Application of Nanoanalysis: Amine-Functionalized Mesoporous Silica nanoparticles for Mercury Speciation in Human Samples. Journal of Nanoanalysis, 2017; 4(3): 181-188. doi: 10.22034/jna.2017.539360

Application of Nanoanalysis: Amine-Functionalized Mesoporous Silica nanoparticles for Mercury Speciation in Human Samples

Article 1, Volume 4, Issue 3, Summer 2017, Page 181-188  XML PDF (681.47 K)
Document Type: Original Research Paper
DOI: 10.22034/jna.2017.539360
Authors
Sara Davari1; Hamid Shirkhanloo 2; Negar Motakef Kazemi1
1Department of Medical Nanotechnology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, (IAUPS), Tehran, Iran
2Research Institute of Petroleum Industry (RIPI), West Entrance Blvd., Olympic Village, Tehran, Iran
Abstract
Mercury (Hg) causes hazardous cumulative effects in humans; like central nervous system disorders,
hypertension and chromosomal aberrations. Therefore, due to high toxicity and bioaccumulation
factor, mercury determination and speciation in human blood is very important. A sensitive,
accurate, precise and inexpensive method was demonstrated for preconcentration and speciation
of ultra-trace mercury in human blood samples. The amine-functionalized mesoporous silica
nanoparticles (NH2-MSNPs) as solid phase sorbent was prepared and investigated in a new and
simple dispersive-ionic liquid-micro-solid phase extraction (D-IL-μ-SPE) procedure for rapid
speciation and determination of trace inorganic and organic mercury [Hg+2 , (CH3Hg)+ and (C2H5Hg)+]
in human blood samples. Under the optimal conditions, the linear range, limit of detection and
preconcentration factor were obtained 0.05-9.8 μg L−1, 15 ng L−1 and 9.6 for human blood samples,
respectively (Peak Area, RSD<5%). The reusability and batch adsorption capacity of the MSNPs
and NH2-MSNPs were also obtained 25 and 159 mg g-1, respectively. The developed method was
successfully applied for validation of methodology by standard reference materials (SRM).
Keywords
Amine-functionalized mesoporous silica nanoparticles; Dispersive-ionic liquid-micro-solid phase extraction; Mercury species; Human blood
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