shahabadi, N., Razlansari, M. (2018). Biological application of Layered double hydroxides in drug delivery systems. Journal of Nanoanalysis, (), -. doi: 10.22034/jna.2018.567196.1088
nahid shahabadi; Mahtab Razlansari. "Biological application of Layered double hydroxides in drug delivery systems". Journal of Nanoanalysis, , , 2018, -. doi: 10.22034/jna.2018.567196.1088
shahabadi, N., Razlansari, M. (2018). 'Biological application of Layered double hydroxides in drug delivery systems', Journal of Nanoanalysis, (), pp. -. doi: 10.22034/jna.2018.567196.1088
shahabadi, N., Razlansari, M. Biological application of Layered double hydroxides in drug delivery systems. Journal of Nanoanalysis, 2018; (): -. doi: 10.22034/jna.2018.567196.1088
Biological application of Layered double hydroxides in drug delivery systems
Articles in Press, Accepted Manuscript , Available Online from 03 August 2018
2Chemistry department, institute of nanotechnology, razi university, Kermanshah, iran
Abstract
This review focuses on the extensive study of different layer double hydroxides (LDHs) nanostructures and also their biological and physicochemical (in vitro) properties to encapsulate and deliver drugs with a recognized pharmacokinetic profile in a sustained/modified manner for better remedial efficacy contrasted to the corresponding conventional treatments using free drugs. LDHs known as hydrotalcite like compounds possess positive charges due to isomorphic substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which are more potent for their protection and controlled‐release. In addition, this composite material exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which would guarantee its practical applications in cancer therapy.Development of new pharmaceutical formulations is observed, based on LDHs, for cancer therapy.