Biological application of Layered double hydroxides in drug delivery systems

shahabadi, nahid; Razlansari, Mahtab

doi:10.22034/jna.2018.567196.1088

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	Biological application of Layered double hydroxides in drug delivery systems
Articles in Press, Accepted Manuscript , Available Online from 03 August 2018
Document Type: Review Paper
DOI: 10.22034/jna.2018.567196.1088
Authors
nahid shahabadi ¹; Mahtab Razlansari²
¹razi university
²Chemistry department, institute of nanotechnology, razi university, Kermanshah, iran
Abstract
This review focuses on the extensive study of different layer double hydroxides (LDHs) nanostructures and also their biological and physicochemical (in vitro) properties to encapsulate and deliver drugs with a recognized pharmacokinetic profile in a sustained/modified manner for better remedial efficacy contrasted to the corresponding conventional treatments using free drugs. LDHs known as hydrotalcite like compounds possess positive charges due to isomorphic substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which are more potent for their protection and controlled‐release. In addition, this composite material exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which would guarantee its practical applications in cancer therapy.Development of new pharmaceutical formulations is observed, based on LDHs, for cancer therapy.
Keywords
Layered double hydroxides; Biological application; Drug Delivery; Release study


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