Histopathological study on acute toxicity of nanochelating based silver nanoparticles in mouse model

Hoseini-Alfatemi, Seyedeh Mahsan; Fallah, Fatemeh; Karimi, Abdollah; Hafizi, Maryam; Armin, Shahnaz; Kalanaki, Somaye

doi:10.22034/jna.2019.668025

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	Histopathological study on acute toxicity of nanochelating based silver nanoparticles in mouse model
Article 2, Volume 6, Issue 3, Summer 2019, Page 157-161 PDF (521.03 K)
Document Type: Original Research Paper
DOI: 10.22034/jna.2019.668025
Authors
Seyedeh Mahsan Hoseini-Alfatemi¹; Fatemeh Fallah¹; Abdollah Karimi¹; Maryam Hafizi²; Shahnaz Armin ¹; Somaye Kalanaki ³
¹Pediatric Infections Research Center, Research Institute for Children̍s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
²Department of Research and Development, SodourAhrarShargh Company, Tehran, Iran / Cancer Research Center, ShahidBeheshti University of Medical Science, Tehran, Iran
³Department of Research and Development, SodourAhrarShargh Company, Tehran, Iran
Abstract
For the therapeutic application and drug delivery of AgNPs in medicine, pharmacy and cosmetic products, it is essential to know the distribution and local or systemic toxicity associated with them. For this purpose, this study was carried out to assess the potential consequences of skin injection of nanochelating based synthesized AgNPs on the mice models. Nanochelating technology used to design and synthesize the AgNPs. The histopathological findings in skin and tissue of micemodels have assessed via histopathological analysis.All samples were visualized by an independent pathologist. The results of each sample have reported as follows, micrograph of the skin cells have shown the normal architecture and cells in all samples. Moreover, histopathological evaluation of samples have shown normal without any significant pathological changes compared to control groups in volume of derm and epiderm, and the number of fibroblast, neutrophil, and macrophage.In summary, this study has observed no obvious decline of immunological performance and morphological signs of skin damage in the mice caused by nanochelating based AgNPs exposure. These findings could provide a fundamental understanding of the intrinsic toxicity associated with nanochelating based AgNPs on biological models. Moreover, this study would arisetypical attentions on the future applications of nanochelating based AgNPs on human, which is valuable for short-term and low dose treatment in nanomedicines.
Keywords
Histopathological Study; Nanochelating; Silver Nanoparticles; Skin Cytotoxicity


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