Investigation of Antimicrobial and Genotoxic Effects of Fe2O3, NiO and CoO NPs Synthesized by Green Synthesis

Document Type: Original Research Paper


1 Ataturk University, Erzurum Vocational College

2 Department of Nursing, Faculty of Health Sciences, Sakarya University of Applied Sciences, 54187, Sakarya, Turkey

3 Department of Pharmaceutical Basic Sciences, Faculty of Pharmacy, Agri İbrahim Cecen University, 04000, Agrı, Turkey

4 Ahi Evran University, Faculty of Agriculture, Department of Field Corps, 40200 Kırsehir, Turkey

5 Department of Biology, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey



It is seen that metal nanoparticles are used in many areas due to their antimicrobial effects. For this reason, our study focused on the production of -Fe2O3, NiO and CoO NPs of golden nanoparticles, which are easily obtained with the use of Erzincan grape extract, safe to use, environmentally friendly and cost-effective. Metal ions synthesized by the green synthesis method were characterized using the Scanning Electron Microscope (SEM) analysis. From the SEM diagrams of the synthesized nanoparticles, it was determined that the nanoparticles were approximately 5 to 65 nm in size. Both antimicrobial, genotoxicity and cytotoxicity effects were investigated to determine the rates at which nanoparticles can be used as biosafe. Synthesized -Fe2O3, NiO and CoO NPs showed excellent antibacterial properties on pathogen bacteria againist human. In addition, it was determined that -Fe2O3, NiO and CoO M-NPs showed genotoxic properties in parallel with increasing concentrations. This study, as far as we know, is the first report on microbial -Fe2O3, NiO and CoO NPs and their biological properties synthesized by this statistical approach.