Document Type: Original Research Paper
Merwinite (MW) Ca3Mg(SiO4)2, has been successfully prepared by a modified sol-gel method. Optimization in calcination temperature and mechanical milling resulted in a pure and nano-sized powder which characterized by means of X-RAY diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and fourier transform infrared Spectroscopy (FT–IR). We hypothesized that nano-sized merwinite (MW) would mimic more efficiently the nanocrystal structure and function of natural bone apatite, owing to the higher surface area, compare to conventional micron-size merwinite (MW).Hence, we used the unique advantage of nano- biotechnology to improve novel nano merwinite (NMW) particles as a good candidate for tissue regeneration whether as a peri - implant filling powder or in combination with other biomaterials as a composite scaffold.In contrast micron-size particles with lower surface area, lack the potency of homogeneous absorption by osteoclasts and miss the unique advantage of nanotechnology for bioactivity and resorbability. Our study suggests that nanomerwinite (NMW) might be a potential candidate by itself as a nanobioceramic filling powder or in combination with other biomaterials as a composite scaffold in bone regeneration.