An efficient platform based on cupper complex-multiwalled carbon nanotube nanocomposite modified electrode for the determination of uric acid

Document Type: Original Research Paper


Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran



A new voltammetric sensor for determination of uric acid (UA) by Cupper
complex- multiwalled carbon nanotube (Cu-complex-CNT) nanocomposite modified
carbon paste electrode (CPE) is reported. The electrocatalytic behavior of the
Cu-complex-CNT nanocomposite modified CPE was studied in pH 2.0 phosphate
buffer solution by chronoamperometry (CA) and cyclic voltammetry (CV) in the
presence of uric acid. Due to the excellent electrocatalytic activity, enhanced
electrical conductivity and high surface area of the Cu-complex-CNT, determination
of uric acid with well-defined peaks was achieved at the Cu-complex-CNT modified
electrode. The catalytic peak current obtained, was linearly dependent on the
UA concentrations in the range of 0.66 – 350.0μM with sensitivity of 0.05 μA
μM-1. The detection limits for UA were 0.075μM, The diffusion coefficient for the
oxidation of UA at the modified electrode was calculated as (4.1±0.05) ×10−5 cm2
s−1. The proposed sensor was successfully examined in real sample analysis with
urine and human serum and revealed stable and reliable recovery data.