Investigation of Antimicrobial and Genotoxic Effects of Fe2O3, NiO and CoO NPs Synthesized by Green Synthesis

Document Type : Original Research Paper


1 Ataturk University, Erzurum Vocational College

2 2 Department of Nano-Science and Nano-Engineering, Institute of Science and Technology, Ataturk University, 25240 Erzurum, Turkey 3 Department of Nursing, Faculty of Health Sciences, Sakarya University of Applied Sciences, 54187, Sakarya, Turkey

3 Department of Pharmaceutical Basic Sciences, Faculty of Pharmacy, Agri İbrahim Cecen University, 04000, Agrı, Turkey

4 Ahi Evran University, Faculty of Agriculture, Department of Field Corps, 40200 Kırsehir, Turkey

5 Department of Biology, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey



It is seen that metal nanoparticles are used in many areas due to their antimicrobial
effects. For this reason, our study focused on the production of a-Fe2O3, NiO
and CoO NPs of golden nanoparticles, which are easily obtained with the use of
Erzincan grape extract, safe to use, environmentally friendly and cost-effective.
Metal ions synthesized by the green synthesis method were characterized using
the Scanning Electron Microscope (SEM) analysis. From the SEM diagrams of
the synthesized nanoparticles, it was determined that the nanoparticles were
approximately 5 to 65 nm in size. Both antimicrobial, genotoxicity and cytotoxicity effects were investigated to determine the rates at which nanoparticles can be used as biosafe. Synthesized a-Fe2O3, NiO and CoO NPs showed excellent antibacterial properties on pathogen bacteria against human. In addition, it was determined that a-Fe2O3, NiO and CoO M-NPs showed genotoxic properties in parallel with increasing concentrations. This study, as far as we know, is the first report on microbial a-Fe2O3, NiO and CoO NPs and their biological properties synthesized by this statistical approach.