Fabrication of HPA-ZSM-5 and their successful application to the recyclable heterogeneous catalyst for the smooth synthesis of spiro-pyrido-pyrimidine indoline derivatives

Document Type : Original Research Paper

Authors

1 Department of Organic Chemistry, Faculty of Chemistry,University of Kashan, Iran

2 Department of Inorganic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I. R, Iran.

3 Department of Inorganic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I. R, Iran

10.22034/jna.2021.690106

Abstract

A beneficial and efficient one-pot three-component approach for the synthesis of
spiro cyclic 2-oxindole derivatives have been described by the reaction of isatins,
cyclic-1,3-diketones and 6-amino-1,3-dimethyluracil in the presence of highly
active HPA-ZSM-5 microporous catalyst. The zeolite catalyst has been synthesized
and the catalyst has been thoroughly characterized by X-ray diffraction (XRD),
field emission scanning electronic microscopy (FE-SEM), Fourier transform
infrared (FT-IR), energy dispersive spectroscopy (EDS) and N2-adsorption analysis.
HPA-ZSM-5 catalyst exhibited exceptional recyclability at least for 6 times and
the surface acidity was not significantly changed. The best results were gained
in H2O and we found the convincing results in the synthesis of spiro-pyridopyrimidine
in the presence of HPA-ZSM-5 (10 mg) under ultrasound irradiation
(40W). Experimental simplicity, wide range of products, excellent yields in short
reaction times and low catalyst loading are some of the substantial features of
this procedure. The present catalytic method is extensible to a wide diversity of
substrates for the synthesis of a variety-oriented library of spiro-pyrido-pyrimidine
indoline derivatives.

Keywords